🕵️ Spyre Therapeutics, Inc. ($SYRE)
SEC insider & ownership activity, last 12 months · CIK 1636282 · every row links its SEC filing
Over the last 12 months insiders sold $426.4M with no open-market buying against it. Fairmount Funds Management LLC sold $399.7M in discretionary trades (Jun). No red-flag 8-Ks in the window.
Monthly net open-market insider flow, last 12 months (up = net buying)
Insider flow
0 buyers, $0 (0 lots) · 5 sellers, $426.4M (55 lots)
| Insider | Buys | Bought | Sells | Sold | Last |
|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 0 | – | 1 | $399.7M | Jun 23, 2026 |
| Henderson Michael Thomas | 0 | – | 5 | $8.0M | Jun 22, 2026 |
| Sloan Sheldon | 0 | – | 11 | $7.4M | Jul 1, 2026 |
| Turtle Cameron | 0 | – | 25 | $7.3M | Jul 1, 2026 |
| Scott L. Burrows | 0 | – | 13 | $4.2M | Jul 1, 2026 |
5%+ holders
| Holder | Stake | Class | Schedule | Event | |
|---|---|---|---|---|---|
| Tomas Kiselak | 10.0% | 13D | Jun 23, 2026 | filing ↗ | |
| Peter Evan Harwin | 10.0% | 13D | Jun 23, 2026 | filing ↗ | |
| Fairmount Funds Management LLC | 9.2% | 13D | Jun 23, 2026 | filing ↗ | |
| Fairmount Healthcare Fund II L.P. | 9.2% | 13D | Jun 23, 2026 | filing ↗ | |
| Blackrock, Inc. | 6.6% | 13G | Jul 16, 2025 | filing ↗ | |
| RTW Investments, LP | 6.2% | 13G | Feb 14, 2025 | filing ↗ | |
| Roderick WONG, M.D. | 6.2% | 13G | Feb 14, 2025 | filing ↗ | |
| Perceptive Advisors LLC | 5.0% | 13G | Apr 22, 2026 | filing ↗ | |
| Joseph Edelman | 5.0% | 13G | Apr 22, 2026 | filing ↗ | |
| Perceptive Life Sciences Master Fund, Ltd. | 5.0% | 13G | Apr 22, 2026 | filing ↗ |
Planned insider sales (Form 144)
| Seller | Planned | Approx. sale date | |
|---|---|---|---|
| Cameron Turtle | $4.0M | Jul 1, 2026 | filing ↗ |
| Scott Burrows | $1.3M | Jun 25, 2026 | filing ↗ |
| Fairmount Healthcare Fund II L.P. | $399.7M | Jun 23, 2026 | filing ↗ |
| Michael Henderson | $1.8M | Jun 22, 2026 | filing ↗ |
| Sheldon Sloan | $1.2M | Jun 3, 2026 | filing ↗ |
| Michael Henderson | $5.8M | May 8, 2026 | filing ↗ |
| Sheldon Sloan | $5.8M | May 1, 2026 | filing ↗ |
| Scott Burrows | $2.0M | May 1, 2026 | filing ↗ |
| Sheldon Sloan | $401K | Apr 1, 2026 | filing ↗ |
| Scott Burrows | $425K | Mar 3, 2026 | filing ↗ |
| Cameron Turtle | $2.6M | Mar 2, 2026 | filing ↗ |
| Cameron Turtle | $2.2M | Nov 3, 2025 | filing ↗ |
Material events (8-K)
| Item | Event date | |
|---|---|---|
| Reg FD disclosure (7.01) | Jun 15, 2026 | filing ↗ |
| Other events (8.01) | Jun 15, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Jun 15, 2026 | filing ↗ |
| Other events (8.01) | May 29, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | May 29, 2026 | filing ↗ |
| Officer/director changes (5.02) | May 27, 2026 | filing ↗ |
| Shareholder vote (5.07) | May 27, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | May 27, 2026 | filing ↗ |
| Earnings (2.02) | May 5, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | May 5, 2026 | filing ↗ |
| Material agreement (1.01) | Apr 14, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Apr 14, 2026 | filing ↗ |
| Earnings (2.02) | Apr 13, 2026 | filing ↗ |
| Other events (8.01) | Apr 13, 2026 | filing ↗ |
| Reg FD disclosure (7.01) | Apr 13, 2026 | filing ↗ |
| Other events (8.01) | Apr 13, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Apr 13, 2026 | filing ↗ |
| Earnings (2.02) | Feb 19, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Feb 19, 2026 | filing ↗ |
| Reg FD disclosure (7.01) | Jan 12, 2026 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Jan 12, 2026 | filing ↗ |
| Earnings (2.02) | Nov 4, 2025 | filing ↗ |
| Reg FD disclosure (7.01) | Nov 4, 2025 | filing ↗ |
| Other events (8.01) | Nov 4, 2025 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Nov 4, 2025 | filing ↗ |
| Earnings (2.02) | Oct 14, 2025 | filing ↗ |
| Material agreement (1.01) | Oct 13, 2025 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Oct 13, 2025 | filing ↗ |
| Earnings (2.02) | Aug 5, 2025 | filing ↗ |
| Financial Statements and Exhibits (9.01) | Aug 5, 2025 | filing ↗ |